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Antigenic Specificity | CYR61 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cyr61 is a secreted heparin binding protein, encoded by a growth factor-inducible immediate-early gene, that associates with the extracellular matrix and connective tissue. Cyr61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse Cyr61 homolog, Fisp12. As an angiogenic inducer, Cyr61 binds to the cell surface receptor Integrin aV/b3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of Cyr61 is elevated during vessel growth, wound healing and chondrocyte differentiation. Cyr61 is also detected in a wide variety of tumors as it induces tumor growth a |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [CYR61; IGFBP10; IGF binding protein 10; IBP 10; CCN family member 1; CCN1], [CYR61; CYR61; CCN1; GIG1; IGFBP10; CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10] |
Gene, Accession # | [CYR61], Gene ID: 3491, NCBI: O00622.1, UniProt: O00622 |
Catalog # | MBS127972 |
Price | $200, $275, $430 |
Order / More Info | CYR61 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |