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Antigenic Specificity | PTEN |
Clone | [6H2.1] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a |
Format | unconjugated |
Size | 5 Control Slides, 0.1 mL (Concentrate), 3 ml (Prediluted) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Formalin/Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Phosphatase and tensin homolog (PTEN) is a protein that, in humans, is encoded by the PTEN gene. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating Akt/PKB signaling pathway. PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. During tumor development, mutations and deletions of PTEN occur that inactivate its enzymatic activity leading to increased cell proliferation and |
Immunogen | Immunogen: C-terminal 100 aminoacids of PTEN. |
Other Names | [PTEN; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatase and tensin homolog; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog], [PTEN; PTEN; BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; MMAC1; TEP1] |
Gene, Accession # | [PTEN], Gene ID: 5728, NCBI: AAD13528.1 |
Catalog # | MBS370321 |
Price | $130, $265, $265 |
Order / More Info | PTEN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |