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Antigenic Specificity | BCL-10 |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | human, mouse |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. |
Immunogen | Immunogen: Purified recombinant fragment of human BCL-10 expressed in E. Coli. |
Other Names | [CLAP; Me10; CIPER; c-E10; CARMEN], [BCL10; BCL10; CLAP; mE10; CIPER; IMD37; c-E10; CARMEN; CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10] |
Gene, Accession # | [BCL-10], Gene ID: 8915, NCBI: NP_003912.1, UniProt: O95999 |
Catalog # | MBS850837 |
Price | $280 |
Order / More Info | BCL-10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |