Chk2 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Chk2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to Human Chk2. Chk2 is the mammalian orthologue of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases (1-3). The amino-terminal domain of Chk2 contains a series of seven serine or threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) each followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases (4,5). After DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR (5-7). The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributabl |
| Immunogen | Immunogen: A recombinant protein fragment of human Chk2 |
| Other Names | [CHEK2; Chk2; Chk2; CHEK2; CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; Serine/threonine-protein kinase; Chk2; Cds1;], [CHEK2; CHEK2; CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425; CDS1; CHK2; RAD53; Hucds1; hCds1] |
| Gene, Accession # | Gene ID: 11200, NCBI: NP_001005735.1, UniProt: O96017 |
| Catalog # | MBS125309 |
| Price | $200, $275, $430 |
| Order / More Info | Chk2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Allen, J.B. et al. (1994) Genes Dev. 8, 2401-2415. 2. Weinert, T.A. et al. (1994) Genes Dev. 8, 652-665. 3. Murakami, H. and Okayama, H. (1995) Nature 374, 817-819. 4. Kastan, M.B. and Lim, D.S. (2000) Nat. Rev. Mol. Cell Biol. 1, 179-186. 5. Matsuoka, S. et al. (2000) Proc. Natl. Acad. Sci. USA 97, 10389-10394. 6. Melchionna, R. et al. (2000) Nat. Cell Biol. 2, 762-765. 7. Ahn, J.Y. et al. (2000) Cancer Res. 60, 5934-5936. 8. Lee, C.H. and Chung, J.H. (2001) J. Biol. Chem. 276, 30537-30541. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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