Description | Specificity: Mouse CD2/LFA-2 (Mr 45-58 kDa). CD2, also known as leukocyte function-associated antigen-2 (LFA-2), is a member of the immunoglobulin superfamily of cell adhesion molecules.^1 It is expressed on the surface of >95% of thymocytes, and essentially all B cells, T cells and NK cells. ^1-3 In the mouse, CD2 is the receptor for CD48.^4 CD2 is thought to play a major role in mediating T-cell adhesion, T-cell recognition/activation, Tcell signaling and intrathymic differentiation.^5-10. |
Product Specific References | 1. Altevogt, P., U. Kohl, P. von Hoegen, E. Lang, and V. Schirrmacher. 1989. Eur. J. Immunol. 19:341-346.2. Altevogt, P., M. Michaelis, and R.A. and B. A. Kyewski. 1989. Eur. J. Immunol. 19:1509.3. Kato, K., M. Koyanagi, H. Okada, T. Takanashi, Y.W. Wong, A.F. Williams, K. Okumura, and H. Yagita. 1992. J. Exp. Med. 176:1241-1249.4. Guckel, B., C. Berek, M. Lutz, P. Altevogt, V. Schirrmacher, and B.A. Kyewski. 1991. J. Exp. Med. 174:947.5. Shaw, S., G.E.G. Luce, R. Quinones, R.E. Gress, T.A. Springer, and M.E. Sanders. 1986. Nature (London)323:262-264.6. Shaw, S., and G.E.G. Luce. 1987. J. Immunol. 139:1037-1045.7. Bierer, B.E., A. Peterseon, J. Barbosa, B. Seed, and S.J. Burakoff. 1988. Proc. Natl. Acad. Sci. USA 85:1194-1198.8. Alcover, A., D. Ramarli, N.E. Richardson, H. Chang, and E.L. Reinherz. Immunol. Rev. 95:5-36.9. Linch, D.C., D.L. Wallace, and K. O'Flynn. 1987. Immunol. Rev. 95:137-159.10. Selvaraj, O., M.L. Plunkett, M.Dustin, M.E. Sanders, S. Shaw, and T.A. Springer. Nature (London) 326:400-403. |