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Antigenic Specificity | Human IRAK3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | IgG concentration 0.5 mg/ml |
Applications | Immunohistology Paraffin*, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti Human IRAK3 antibody recognizes human Interleukin-1 receptor-associated kinase 3 (IRAK3), a member of the IRAK/Pelle family. IRAKs associate with the IL1/Toll receptors after IL-1 or LPS stimulation, thereby playing an important role in the inflammatory response. IRAK3 inhibits the dissociation of IRAK1 and IRAK4 from the Toll-like receptor signalling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilising the receptor complex. It is predominantly expressed in peripheral blood lymphocytes. Defects in the IRAK3 gene are associated with susceptibility to asthma-related traits type 5. Rabbit anti Human IRAK3 antibody does not cross-react with IRAK or IRAK2. |
Immunogen | Immunogen: Peptide corresponding to amino acids from the carboxy terminus of human IRAK3. Buffer Solution: Phosphate buffered saline Antiserum Preparation: Antisera to human IRAK3 were raised by repeated immunisation of rabbits with highly purified antigen. Target Species: Human |
Other Names | [interleukin-1 receptor-associated kinase 3 isoform b; Interleukin-1 receptor-associated kinase 3; interleukin-1 receptor-associated kinase 3; IL-1 receptor-associated kinase M; IRAK3; interleukin-1 receptor-associated kinase 3; IL-1 receptor-associated kinase M; IRAK-M], [IRAK3; IRAK3; ASRT5; IRAKM; IRAK-3; IRAK-M] |
Gene, Accession # | [IRAK3], Gene ID: 11213, NCBI: NP_001135995.1, UniProt: Q9Y616 |
Catalog # | MBS223357 |
Price | $375 |
Order / More Info | Human IRAK3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |