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Antigenic Specificity | MAPK8IP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 0.3mg/mL |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. |
Immunogen | Immunogen: Synthetic peptide of human MAPK8IP1 Calculated Molecular Weight: 78kDa |
Other Names | [IB1; JIP1; JIP-1; PRKM8IP] |
Gene, Accession # | [MAPK8IP1], NCBI: AIC55594.1 |
Catalog # | MBS2528531 |
Price | $110, $150, $225 |
Order / More Info | MAPK8IP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |