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Antigenic Specificity | Phospho-Synuclein (Ser129) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-Synuclein (Ser129) antibody detects endogenous levels of Synuclein only when phosphorylated at Serine 129. Description: Alpha-synuclein is a member of the synuclein family, which also includes beta-and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha-and beta-synuclein inhibit phospholipase D2 selectively.Function: May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.Subunit Structure: Soluble monomer which can form filamentous aggregates. Interacts with UCHL1 (By similarity). Interacts with phospholipase |
Immunogen | Immunogen: A synthesized peptide derived from human Synuclein around the phosphorylation site of Serine 129 Subcellular Location: Cytoplasm, Cytosol. Membrane. Nucleus. Cell Junction, Synapse. Secreted. Membrane-bound in dopaminergic neurons. Tissue Specificity: Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals. Predicted Cross Reactivity: Pig, Bovine, Horse, Rabbit, Dog, Chicken Similar |
Other Names | [Alpha synuclein; Alpha-synuclein; Alpha-synuclein, isoform NACP140; alphaSYN; MGC105443; MGC110988; MGC127560; MGC64356; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid; Non A4 component of amyloid precursor; Non-A beta component of AD amyloid; Non-A-beta component of alzheimers disease amyloid, precursor of; Non-A4 component of amyloid precursor; Non-A4 component of amyloid, precursor of; OTTHUMP00000218549; OTTHUMP00000218551; OTTHUMP00000218552; OTTHUMP00000218553; OTTHUMP00000218554; PARK 1; PARK 4; PARK1; PARK4; Parkinson disease (autosomal dominant, Lewy body) 4; Parkinson disease familial 1; SNCA; Snca synuclein, alpha (non A4 component of amyloid precursor); SYN; Synuclein alpha; Synuclein alpha 140; Synuclein, alpha (non A4 component of amyloid precursor); SYUA_HUMAN] |
Gene, Accession # | [SNCA], Gene ID: 6622, NCBI: NP_000336.1, UniProt: P37840 |
Catalog # | MBS9601056 |
Price | $240, $280 |
Order / More Info | Phospho-Synuclein (Ser129) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |