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Antigenic Specificity | Catenin, alpha-1 (CTNNA1) |
Clone | [1G5] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-catenin forms a heterodimer with beta-catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-catenin also regulates the beta-catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer. |
Immunogen | Immunogen: Human alpha catenin fusion protein. Cellular Localization: Cell Surface |
Other Names | [Alpha E-catenin; Cadherin-associated protein; CAP102; Catenin alpha-1; CTNNA1; Renal carcinoma antigen NY-REN-13], [CTNNA1; CTNNA1; MDPT2; CAP102] |
Gene, Accession # | [CTNNA1], Gene ID: 1495, NCBI: NP_001277236.1, UniProt: P35221 |
Catalog # | MBS439891 |
Price | $190, $340, $340 |
Order / More Info | Catenin, alpha-1 (CTNNA1) Antibody from MYBIOSOURCE INC. |
Product Specific References | Johnson, KR; Lewis, JE; Li, D; Wahl, J; Soler, AP; Knudsen, KA; Wheelock, MJ. P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res 1993, 207: 252-60. Nieman, MT; Kim, JB; Johnson, KR; Wheelock, MJ. Mechanism of extracellular domain-deleted dominant negative cadherins. J Cell Science 1999, 112: 1621-3. |