MARCKS Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-MARCKS antibody, protein, ELISA kits.
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| Antigenic Specificity | MARCKS |
| Clone | polyclonal |
| Host Species | Chicken |
| Reactive Species | human. predicted: nonhuman primate |
| Isotype | n/a |
| Format | IgY fraction |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for endogenous levels of the ~80 kDa MARCKS protein. Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is a major substrate for phosphorylation by protein kinase C (PKC) (Ouimet et al.,1990) and is concentrated in synapses of neurons. It appears to function in synaptic vesicle cycling and has been shown to bind both actin and calmodulin in vitro (Hartwig et al. 1992). Deletion of the MARCKS gene in mice results in embryonic brain defects and death (Stumpo et al. 1995). MARCKS is a member of a family of calmodulin binding proteins and phosphorylation of Ser152/156 modulates the binding of MARCKS to calmodulin (Verghese et al., 1994). |
| Immunogen | Immunogen Species: Human. Immunogen Information: Recombinant human MARCKS expressed in and purified from E Coli. |
| Other Names | [myristoylated alanine-rich C-kinase substrate; Myristoylated alanine-rich C-kinase substrate; myristoylated alanine-rich C-kinase substrate; myristoylated alanine rich protein kinase C substrate; Protein kinase C substrate, 80 kDa protein, light chain], [MARCKS; MARCKS; MACS; 80K-L; PKCSL; PRKCSL; MACS; PRKCSL; MARCKS; 80K-L protein; PKCSL] |
| Gene, Accession # | [MARCKS], Gene ID: 4082, NCBI: NP_002347.5, UniProt: P29966 |
| Catalog # | MBS500078 |
| Price | $360 |
| Order / More Info | MARCKS Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Ouimet CC, Wang JKT, Walaas SI, Albert KA, Greengard P (1990) Localization of the MARCKS (87 kDa) protein, a major specific substrate for protein kinase C, in rat brain. J Neurosci 10:1683-1698. 2. Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC and Aderem A. (1992) MARCKS is an actinfilament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature 356: 618-622. 3. Stumpo DJ, Bock CB, Tuttle JS and Blackshear PJ. (1995) MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Proc. Nat. Acad. Sci. 92; 944-948. 4. Verghese GM, Johnson JD, Vasulka C, Haupt DM, Stumpo DJ, Blackshear PJ (1994) Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. J Biol Chem 269:9361-9367. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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