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Antigenic Specificity | WWTR1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.8mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total WWTR1 protein. Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional |
Immunogen | Immunogen: Fusion protein of human WWTR1 Immunogen Type: Protein |
Other Names | [TAZ] |
Gene, Accession # | [WWTR1], Gene ID: 25937, NCBI: BC014052, UniProt: Q9GZV5 |
Catalog # | MBS9430190 |
Price | $255 |
Order / More Info | WWTR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |