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Antigenic Specificity | BMI1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The polycomb group (PcG) of proteins contributes to the maintenance of cell identity, stem cell self-renewal, cell cycle regulation, and oncogenesis by maintaining the silenced state of genes that promote cell lineage specification, cell death, and cell-cycle arrest (1-4). PcG proteins exist in two complexes that cooperate to maintain long-term gene silencing through epigenetic chromatin modifications. The first complex, EED-EZH2, is recruited to genes by DNA-binding transcription factors and methylates histone H3 on Lys27. This histone methyl-transferase activity requires the Ezh2, Eed, and Suz12 subunits of the complex (5). Histone H3 methylation at Lys27 facilitates the recruitment of the second complex, PRC1, which ubiquitinylates histo |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [BMI1; Polycomb complex protein BMI 1; RING finger protein 51; RNF51; PCGF4], [COMMD3-BMI1; BMI1; PCGF4; RNF51] |
Gene, Accession # | [BMI1], Gene ID: 100532731, NCBI: P35226.2, UniProt: P35226 |
Catalog # | MBS125291 |
Price | $200, $275, $430 |
Order / More Info | BMI1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |