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Antigenic Specificity | Human XAF1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.05 mg |
Concentration | 1 mg/ml |
Applications | Immunohistochemistry (IHC - Paraffin), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: synthetic peptide corresponding to 16 amino acids near the middle of human XAF-1. XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death. XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. |
Immunogen | Immunogen Description: Synthetic peptide from human XAF1. |
Other Names | [XAF1 IHC-plus; XAF1; BIRC4 binding protein; BIRC4-binding protein; BIRC4BP; HSXIAPAF1; XIAP-associated factor 1; XIAPAF1; XIAP associated factor 1; Human XAF1], [XAF1; XAF1; BIRC4BP; XIAPAF1; HSXIAPAF1; BIRC4BP; XIAPAF1] |
Gene, Accession # | [XAF1], Gene ID: 54739, NCBI: NP_059993.2, UniProt: Q6GPH4 |
Catalog # | MBS241350 |
Price | $660 |
Order / More Info | Human XAF1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |