HSP90 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHSP90
Clone[4F3.E8]
Host SpeciesMouse
Reactive Specieshuman, mouse, rat, plant
IsotypeIgG2a
FormatAPC-Cy7 conjugate
Size0.2 mg
Concentration1 mg/ml
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA (EIA)
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DescriptionDetects ~90 kDa. This antibody detects both alpha and beta forms of HSP90 equally well. HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms alpha and beta, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). Despite the similarities, HSP90alpha exists predominantly as a homodimer while HSP90beta exists mainly as a monomer (2). From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (3-6). Furthermore, HSP90 is highly conserved between species; having 60% and 78% amino acid similarity between
ImmunogenImmunogen: Recombinant Human HSP90 purified from E.coli
Other Names[Mouse Human HSP90 (total) IgG2a; HSP90 (total) : APC/Cy7; HSP84; HSP86; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSPC1; HSPC2; HSPCAL1; HSPCAL4]
Gene, Accession #[HSP90], Gene ID: 3320, NCBI: NP_001017963.2, UniProt: P07900
Catalog #MBS8002314
Price$650
Order / More InfoHSP90 Antibody from MYBIOSOURCE INC.
Product Specific References1. Nemoto T. et al. (1997) J.Biol Chem. 272: 26179-26187. 2. Minami, Y, et al. (1991), J.Biol Chem. 266: 10099-10103. 3. Arlander SJH, et al. (2003) J Biol Chem 278: 52572-52577. 4. Pearl H, et al. (2001) Adv Protein Chem 59: 157-186. 5. Neckers L, et al. (2002) Trends Mol Med 8: S55-S61. 6. Pratt W, Toft D. (2003) Exp Biol Med 228: 111-133. 7. Pratt W, Toft D. (1997) Endocr Rev 18: 306-360. 8. Pratt WB. (1998) Proc Soc Exptl Biol Med 217: 420-434. 9. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91: 8324-8328. 10. Nemoto, T. (1997) Biochem and Mol. Bio Intl. 42 (5): 881-889.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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