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Antigenic Specificity | HSP90 |
Clone | [4F3.E8] |
Host Species | Mouse |
Reactive Species | human, mouse, rat, plant |
Isotype | IgG2a |
Format | APC-Cy7 conjugate |
Size | 0.2 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects ~90 kDa. This antibody detects both alpha and beta forms of HSP90 equally well. HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms alpha and beta, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment (1). Despite the similarities, HSP90alpha exists predominantly as a homodimer while HSP90beta exists mainly as a monomer (2). From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (3-6). Furthermore, HSP90 is highly conserved between species; having 60% and 78% amino acid similarity between |
Immunogen | Immunogen: Recombinant Human HSP90 purified from E.coli |
Other Names | [Mouse Human HSP90 (total) IgG2a; HSP90 (total) : APC/Cy7; HSP84; HSP86; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSPC1; HSPC2; HSPCAL1; HSPCAL4] |
Gene, Accession # | [HSP90], Gene ID: 3320, NCBI: NP_001017963.2, UniProt: P07900 |
Catalog # | MBS8002314 |
Price | $650 |
Order / More Info | HSP90 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Nemoto T. et al. (1997) J.Biol Chem. 272: 26179-26187. 2. Minami, Y, et al. (1991), J.Biol Chem. 266: 10099-10103. 3. Arlander SJH, et al. (2003) J Biol Chem 278: 52572-52577. 4. Pearl H, et al. (2001) Adv Protein Chem 59: 157-186. 5. Neckers L, et al. (2002) Trends Mol Med 8: S55-S61. 6. Pratt W, Toft D. (2003) Exp Biol Med 228: 111-133. 7. Pratt W, Toft D. (1997) Endocr Rev 18: 306-360. 8. Pratt WB. (1998) Proc Soc Exptl Biol Med 217: 420-434. 9. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91: 8324-8328. 10. Nemoto, T. (1997) Biochem and Mol. Bio Intl. 42 (5): 881-889. |