AATF Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | AATF |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous levels of total AATF protein. May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.Lindfors K., Biochem. Biophys. Res. Commun. 276:660-666(2000).Fanciulli M., FASEB J. 14:904-912( |
| Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from N-terminal of human AATF. |
| Other Names | [CHE-1; CHE1; DED; apoptosis antagonizing transcription factor] |
| Gene, Accession # | [AATF], Gene ID: 26574, NCBI: NP_036270.1, UniProt: Q9NY61 |
| Catalog # | MBS9407456 |
| Price | $200, $255 |
| Order / More Info | AATF Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.