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Antigenic Specificity | CGAS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 0.78mg/mL |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2', 5' phosphodiester linkage at the GpA step and the formation of a 3', 5' phosphodiester linkage at the ApG step, producing c[G(2', 5')pA(3', 5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contr |
Immunogen | Immunogen: Synthetic peptide of human MB21D1 |
Other Names | [C6orf150; CGAMP synthase; CGAS; CGAS; CGMP Synthase; Chromosome 6 open reading frame 150; Cyclic GMP-AMP synthase; H-cGAS; Hypothetical protein LOC115004; Mab 21 domain containing 1; Mab-21 domain-containing protein 1; MB21D1; MGC131892; MGC142166; MGC142168; OTTHUMP00000016743; OTTHUMP00000039330; Protein MB21D1; Uncharacterized protein C6orf150] |
Gene, Accession # | [CGAS], Gene ID: 115004, NCBI: NP_612450, UniProt: Q8N884 |
Catalog # | MBS2559732 |
Price | $110, $150, $225 |
Order / More Info | CGAS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |