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Antigenic Specificity | BRE |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1 mg/ml |
Applications | Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between MERIT40/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex. |
Immunogen | Immunogen: BRE antibody was raised in rabbit using a recombinant protein fragment contain a sequence corresponding to a region within amino acids 9 and 328 of BRCC45 |
Other Names | [Affinity Purified Rabbit BRE; BRE; BRE; BRCA1/BRCA2-containing complex subunit 4; BRCC4; brain and reproductive organ-expressed protein; BRE; BRCA1/BRCA2-containing complex subunit 45; BRCA1-A complex subunit BRE; BRCC45] |
Gene, Accession # | [BRE] |
Catalog # | MBS5312012 |
Price | $485 |
Order / More Info | BRE Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |