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Antigenic Specificity | NME2/nm23-H2/NDPK-B (Suppressor of Metastasis) |
Clone | [CPTC-NME2-2] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG2a |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistology (Formalin-Fixed) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human c-Myc promotor. |
Immunogen | Immunogen: Recombinant full-length human NME2 protein Positive Control: HeLa, Jurkat Cells. Ubiquitously expressed in all tissues. |
Other Names | [C myc purine binding transcription factor PUF; C myc transcription factor; C-myc purine-binding transcription factor PUF; epididymis secretory sperm binding protein Li 155an; HEL-S-155an; Histidine protein kinase NDKB; NDK B; NDKB; NDP kinase B; NDPK B; NDPKB; NM23 H2; nm23-H2; NM23B; NME/NM23 nucleoside diphosphate kinase 2; nme2; Non metastatic cells 2, protein (NM23B) expressed in; non-metastatic cells 2, protein (NM23) expressed in; Nucleoside diphosphate kinase B; Nucleotide diphosphate kinase B; PUF] |
Gene, Accession # | [NME2], Gene ID: 654364, NCBI: NP_001018146.1, UniProt: P22392 |
Catalog # | MBS4380647 |
Price | $190, $340, $340 |
Order / More Info | NME2/nm23-H2/NDPK-B (Suppressor of Metastasis) Antibody from MYBIOSOURCE INC. |
Product Specific References | Tong, Y., et al. 2015. Cancer Lett. 361: 207-21 |