NEB2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | NEB2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: NEB2 antibody detects endogenous levels of total NEB2. Function: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 recep |
| Immunogen | Immunogen: A synthesized peptide derived from human NEB2 Subcellular Location: Cytoplasm > Cytoskeleton. Nucleus. Cell Projection > Dendritic Spine. Cell Junction > Synapse. Cell Junction > Adherens Junction. Cytoplasm. Cell Membrane. Cell Projection > Lamellipodium. Cell Projection > Filopodium. Cell Projection > Ruffle Membrane. Enriched at synapse and cadherin-based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the post-synaptic density a |
| Other Names | [FLJ30345; NEB2_HUMAN; Neurabin II; Neurabin-2; Neurabin-II; Neurabin2; NeurabinII; Neural tissue specific F actin binding protein II; p130; PP1bp134; PPP1R6; PPP1R9; Ppp1r9b; Protein phosphatase 1 regulatory subunit 9B; SPINO; Spinophilin] |
| Gene, Accession # | [NEB2], Gene ID: 84687, NCBI: NP_115984.3, UniProt: Q96SB3 |
| Catalog # | MBS9602934 |
| Price | $240, $280 |
| Order / More Info | NEB2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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