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Antigenic Specificity | LIM Kinase 1 (LIMK1) (N-term), 1-30 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: mouse, rat) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This LIM Kinase 1 (LIMK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LIM Kinase 1 (LIMK1). LIMK1, a member of the Ser/Thr protein kinase family, may be a component of an intracellular signaling pathway and may be involved in brain development. It phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes. The LIM domain interacts with the cytoplasmic domain of NRG1, and this cytoplasmic protein also binds ROCK1, whic phosphorylates LIMK1 on serine and/or threonine residues. Highest expression occurs in both adult and fetal nervous systems. It is detected ubiquitously throughout the |
Immunogen | n/a |
Other Names | [LIM domain kinase 1; LIMK-1; LIMK1; LIMK] |
Gene, Accession # | [LIMK1], Gene ID: 3984, NCBI: NP_001191355.1, UniProt: P53667 |
Catalog # | MBS9207050 |
Price | $165, $370 |
Order / More Info | LIM Kinase 1 (LIMK1) (N-term), 1-30 Antibody from MYBIOSOURCE INC. |
Product Specific References | Ohashi, K., et al., J. Biol. Chem. 275(5):3577-3582 (2000). Maekawa, M., et al., Science 285(5429):895-898 (1999). Edwards, D.C., et al., J. Biol. Chem. 274(16):11352-11361 (1999). Osborne, L.R., et al., Genomics 36(2):328-336 (1996). Frangiskakis, J.M., et al., Cell 86(1):59-69 (1996). |