Collagen II, Mouse Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCollagen II, Mouse
CloneM2139
Host SpeciesMouse
Reactive Speciesreactivity: mouse. cross reactivity: bovine, chicken, human, rat
IsotypeIgG2b
Formatunconjugated
Size0.1 mg
Concentrationn/a
ApplicationsF, FS, Immunoassay (IA), P, Immunohistochemistry (IHC)
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DescriptionProduct Description: The monoclonal antibody M2139 reacts with the J1 epitope (triple helical position 551-564) of collagen type II. Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA). The monocolonal antibody M2139 has been shown to induce CAIA in na ve mice after injection of lipopolysacharide (LPS). However, in combination wi
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #MBS584241
Price$555
Order / More InfoCollagen II, Mouse Antibody from MYBIOSOURCE INC.
Product Specific References1. Nandakumar, K et al; Collagen Type II-specific monoclonal antibody-induced arthritis in mice. Description of the disease and the influence of age, sex and genes. Am J Pathol 2003, 163: 1827 2. Nandakumar, K et al; Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. Arthritis Res Ther 2004, 6: R544
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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