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Antigenic Specificity | Tetanus Toxin, Clostridium tetani (Tetanospasmin, TeNT) |
Clone | [9B138] |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG1 |
Format | Protein G purified |
Size | 1 mg |
Concentration | 10.7 mg/ml |
Applications | ELISA (EL/EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes the tetanus toxin. Has toxin neutralization activity (in vivo assay). Tetanus toxin is polypeptide composed of two chains [A chain (55kD) and B chain (105kD)]. The toxin is carried to CNS via bloodstream. Tetanus toxin binds at neuromuscular synapses via ganglioside receptors (sialic acid) via B-chain. The toxin is then internalized via receptor-mediated endocytosis. The A chain is thought to be the toxic subunit by analogy to diptheria and cholera toxin. It has no known effect on any cellular enzyme systems. The action of the holotoxin (A + B chains) is to interfere with synaptic transmission by preferentially inhibiting the release of inhibitory neurotransmitters such as glycine and GABA from inhibitory neurons. This inhibition |
Immunogen | Immunogen: Supernatant from C. tetani. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS632310 |
Price | $730 |
Order / More Info | Tetanus Toxin, Clostridium tetani (Tetanospasmin, TeNT) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |