Edit |   |
---|---|
Antigenic Specificity | MAP3K4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 1.3mg/mL |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, bu |
Immunogen | Immunogen: Synthetic peptide of human MAP3K4 |
Other Names | [MTK1; MEKK4; MAPKKK4; PRO0412] |
Gene, Accession # | [MAP3K4], Gene ID: 4216, NCBI: NP_001288001.1 |
Catalog # | MBS2527143 |
Price | $110, $150, $225 |
Order / More Info | MAP3K4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |