Description | Specificity: GFAP-delta stains the astrocytes loCated in the subpial zone of the cerebral cortex, the subventricular zone of the hippocampus and, most intensely, a ribbon of astrocytes following the ependymal layer of the cerebral ventricles. Human GFAP-delta, also termed GFAP-epsilon, is an alternative splice variant of the GFAP protein. GFAP proteins are selectively loCated in astrocytes and represent the major constituent of astrocytic intermediate filaments. GFAP expression levels are highly variable during development of the central nervous system. GFAP-delta differs from the predominant splice form of GFAP, GFAP-alpha, in its C-terminal sequence in which the original amino acid sequence, encoded by exons 8 and 9, are replaced by a uni |
Product Specific References | Roelofs, R. F., Fischer, D. F., Houtman, S. H., Sluijs, J. A., van Haren, W., van Leeuwen, F. W., and Mol, E. M. (2005). Adult Human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton, GLIA 52, 289-300. Nielsen A. L., Holm, I. E., Johansen, M., Bonven, B., Jorgensen, P., Jorgensen, A. L., (2002). A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins. J. Biol. Chem. 277, 29983-91. |