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Antigenic Specificity | RIP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | serum |
Size | 0.05 mL |
Concentration | n/a |
Applications | Immunoprecipitation (IP), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | RIP (Receptor Interacting Protein) is a 74 kD Ser/Thr kinase which interacts with CD95 (Fas/APO1) receptor and the tumor necrosis factor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRADD, RAID (CRADD) and TRAF2. RIP contains an N terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C terminal region containing an intracellular death domain motif. RIP activates both p38 MAP Kinase and SAPK families. In vitro, RIP induces apoptosis, as well as SAPK/JNK and NF-kB activation. NF-kB activation through TRADD, TRAF2 and RIP can be triggered also by DR3/APO3 upon activation with APO3/Tweak ligand. DR4 and DR5 also use FADD, TRADD, and |
Immunogen | Immunogen Information: A synthetic peptide of human RIP1 (amino acids 269-287 EANPEARPTFPGIEEKFRP) was used as immunogen for this antibody |
Other Names | [AGFG1; HRB; RAB; RIP; HIV-1 Rev-binding protein; Nucleoporin-like protein RIP; Rev-interacting protein; Rev/Rex activation domain-binding protein; to RIP1/TANK; RIP1/TANK; RIP1/TANK], [AGFG1; AGFG1; HRB; RAB; RIP; HRB; RAB; RIP] |
Gene, Accession # | [RIP], Gene ID: 3267, NCBI: P52594.2, UniProt: P52594 |
Catalog # | MBS668767 |
Price | $270 |
Order / More Info | RIP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |