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Antigenic Specificity | ATG3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human ATG3 (NP 071933.2). |
Other Names | [APG3; APG3L; PC3-96; APG3-LIKE] |
Gene, Accession # | [ATG3], Gene ID: 64422, NCBI: NP_071933, UniProt: Q9NT62 |
Catalog # | MBS8545807 |
Price | $280 |
Order / More Info | ATG3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |