Edit |   |
---|---|
Antigenic Specificity | COPS2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human COPS2 (NP 004227.1). |
Other Names | [CSN2; SGN2; ALIEN; TRIP15] |
Gene, Accession # | [COPS2], Gene ID: 9318, NCBI: NP_001137359.1, UniProt: P61201 |
Catalog # | MBS8546531 |
Price | $280 |
Order / More Info | COPS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |