Human Fas-Associated Death Domain Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human Fas-Associated Death Domain |
| Clone | [PJ1D2AT] |
| Host Species | Mouse |
| Reactive Species | n/a |
| Isotype | IgG2b k |
| Format | Protein G purified |
| Size | 0.005 mg, 0.02 mg, 0.1 mg |
| Concentration | n/a |
| Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Introduction: FADD is an adaptor protein that cooperates with a variety of cell surface receptors and mediates cell apoptotic signals. Using its C-terminal death domain, FADD is recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and consequently it take parts in the death signaling initiated by these receptors. FADD interaction with the receptors reviels the N-terminal effector domain of, which allows it to recruit caspase-8, and thus initiate the cysteine protease cascade. Knockout studies in mice furthermore propose the significance of FADD in premature T cell development. FADD plays a role in survival/proliferation and cell cycle development. FADD also takes part in cellular sublocali |
| Immunogen | Immunogen: Anti-human FADD mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human FADD amino acids 1-208 purified from E Coli. |
| Other Names | [FADD; Fas-Associated Death Domain, Mouse Human; GIG3; MORT1; MGC8528; FADD; Fas (TNFRSF6)-associated via death domain; Protein FADD; FAS-associated death domain protein; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; Growth-inhibiting gene 3 protein], [FADD; FADD; GIG3; MORT1; MORT1] |
| Gene, Accession # | [FADD], Gene ID: 8772, NCBI: NP_003815.1 |
| Catalog # | MBS140247 |
| Price | $140, $205, $505 |
| Order / More Info | Human Fas-Associated Death Domain Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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