Human CD8 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human CD8 |
| Clone | [OKT-8] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.025 mg, 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the alpha3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
| Immunogen | n/a |
| Other Names | [Human CD8; T-cell surface glycoprotein CD8 alpha chain; CD8A; T-lymphocyte differentiation antigen T8/Leu-2; MAL] |
| Gene, Accession # | [CD8], Gene ID: 925, NCBI: NP_001139345.1, UniProt: P01732 |
| Catalog # | MBS2553957 |
| Price | $60, $90 |
| Order / More Info | Human CD8 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Knapp W. W. Knapp. et al.Oxford University Press; 1989; :1-1182. 2. Reimann KA, Waite BC, Lee-Parritz DE, et al. Cytometry. 1994; 17(1):102-108. 3. Roederer M, Kantor AB, Parks DR, Herzenberg LA. Cytometry. 1996; 24(3):191-197. 4. Schlossman SF. Stuart F. Schlossman. et al. Oxford University Press; 1995. 5. Sopper S, Stahl-Hennig C, Demuth M, Johnston IC, Dorries R, ter Meulen V. Cytometry. 1997; 29(4):351-362. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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