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Antigenic Specificity | Musk |
Clone | [1429CT456.173.44] |
Host Species | Mouse |
Reactive Species | mouse, rat |
Isotype | IgG1,k |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This mouse Musk antibody is generated from a mouse immunized with recombinant protein from mouse Musk. Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate A |
Immunogen | n/a |
Other Names | [Muscle; skeletal receptor tyrosine-protein kinase; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor; Musk; Nsk2] |
Gene, Accession # | [Musk], Gene ID: 18198, NCBI: NP_001032205.1, UniProt: Q61006 |
Catalog # | MBS9200303 |
Price | $165, $370 |
Order / More Info | Musk Antibody from MYBIOSOURCE INC. |
Product Specific References | Caruso A.,et al.Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases. Ganju P.,et al.Oncogene 11:281-290(1995). DeChiara T.M.,et al.Cell 85:501-512(1996). Glass D.J.,et al.Cell 85:513-523(1996). Lin W.,et al.Nature 410:1057-1064(2001). |