Muscarinic acetylcholine receptor M2, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Muscarinic acetylcholine receptor M2, Human |
| Clone | B8E5 |
| Host Species | Mouse |
| Reactive Species | reactivity: human. cross reactivity: guinea pig, mouse, rat |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, FS, Immunoassay (IA), Immunofluorescence (IF), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody B8E5 recognizes human muscarinic acetylcholine receptor M2 (M2 receptor), a G protein-coupled cardiovascular receptor of ~55 kDa. This receptor is an integral membrane protein consisting of seven membrane spanning a-helices linked together by extra- and intracellular loops that form a pharmacophore pocket. Autoantibodies directed against cardiovascular G protein-coupled receptors functionally interfering with the target have been described in several cardiovascular diseases. The M2 receptor is the predominant sybtype of muscarinic receptors present in the heart of mammalian species. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclas |
| Immunogen | Immunogen: Peptide VRTVEDGECYIQFFSNAAVTFGTAI(C): Human second extracellular loop residues 168-192 |
| Other Names | [M2ACh-R], [CHRM2; CHRM2; HM2] |
| Gene, Accession # | Gene ID: 1129, NCBI: NP_001006633.1 |
| Catalog # | MBS584460 |
| Price | $555 |
| Order / More Info | Muscarinic acetylcholine receptor M2, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Fu, L et al; Agonist-like activity of anti-peptide antibodies directed against an autoimmune epitope on the heart muscarinic acetylcholine receptor. Receptors Channels 1994, 2: 121 2. Elies, R et al; Immunochemical and functional characterization of an agonist-like monoclonal antibody against the M2 acetylcholine receptor. Eur J Biochem 1998, 251: 659 v 3. Nascimento, J et al; cGMP-mediated inhibition of cardiac L-type Ca2 current by a monoclonal antibody against the M2 ACh receptor. Am J Physiol Cell Physiol 2001, 281: 1251 |
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