CASP6 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | CASP6 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes (1, 2). Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated (3). The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis (4, 5). One of the major targets for caspase-6 is the membrane associated protein lamin A (6). The cleavage of this protein causes cell membrane malfunction, membrane blebbing and eventual cell death. |
| Immunogen | Immunogen: Recombinant protein of human CASP6 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [MCH2; CASP6; Caspase-6] |
| Gene, Accession # | [CASP6], Gene ID: 839, NCBI: NP_001217.2, UniProt: P55212 |
| Catalog # | MBS8501257 |
| Price | $310 |
| Order / More Info | CASP6 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Cohen, G.M. (1997) Biochem J 326 (Pt 1), 1-16. 2. Faleiro, L. et al. (1997) EMBO J 16, 2271-81. 3. Li, P. et al. (1997) Cell 91, 479-89. 4. Slee, E.A. et al. (1999) J Cell Biol 144, 281-92. 5. MacFarlane, M. et al. (1997) J Cell Biol 137, 469-79. 6. Orth, K. et al. (1996) J Biol Chem 271, 16443-6. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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