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Antigenic Specificity | PARK7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorecence (IF), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Parkinson's disease (PD) is characterized by the presence of Lewy bodies (intracellular inclusions) and by the loss of dopaminergic neurons. Research studies have shown that mutations in alpha-synuclein, Parkin, and DJ-1 are linked to PD (1). alpha-synuclein is a major component of the aggregates found in Lewy bodies. Parkin is involved in protein degradation through the ubiquitin-proteasome pathway, and investigators have shown that mutations in Parkin cause early onset of PD (1). Loss-of-function mutations in DJ-1 cause early onset of PD, but DJ-1 is associated with multiple functions: it cooperates with Ras to increase cell transformation, it positively regulates transcription of the androgen receptor, and it may function as an indicator |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [PARK7; DJ-1; DJ1; FLJ27376; FLJ34360; FLJ92274], [PARK7; PARK7; DJ1; DJ-1; HEL-S-67p] |
Gene, Accession # | [PARK7], Gene ID: 11315, NCBI: Q99497.2, UniProt: Q99497 |
Catalog # | MBS127379 |
Price | $200, $275, $430 |
Order / More Info | PARK7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |