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Antigenic Specificity | HUCE1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total HUCE1 protein. Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.Yazaki M., Submitted (AUG-1996) to the EMBL/GenBank/DDBJ database |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human HUCE1. |
Other Names | [KIAA0409] |
Gene, Accession # | [HUCE1], Gene ID: 23378, NCBI: NP_056139.1, UniProt: O43159 |
Catalog # | MBS9409863 |
Price | $200, $255 |
Order / More Info | HUCE1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |