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Antigenic Specificity | DACH1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: DACH1 antibody detects endogenous levels of DACH1. Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).Subunit Structure |
Immunogen | Immunogen: A synthesized peptide derived from human DACH1. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen. Predicted Cross Reactivity: Pig, Rabbit, Chicken, Xenopus Similarity: Pig (100%), Rabbit (100%), Chicken (100%), Xenopus (88%) |
Other Names | [DACH; Dach1; DACH1_HUMAN; dachshund homolog 1 (Drosophila); Dachshund homolog 1; Dachsund homolog 1; FLJ10138; OTTHUMP00000018494] |
Gene, Accession # | [DACH1], Gene ID: 1602, NCBI: NP_004383.4, UniProt: Q9UI36 |
Catalog # | MBS9603236 |
Price | $240, $280 |
Order / More Info | DACH1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |