CTCFL (C-Term) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CTCFL (C-Term) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.05 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for |
| Immunogen | n/a |
| Other Names | [Purified Rabbit (Pab); Transcriptional repressor CTCFL; Brother of the regulator of imprinted sites; CCCTC-binding factor; CTCF paralog; CTCF-like protein; Cancer/testis antigen 27; CT27; Zinc finger protein CTCF-T; CTCFL; BORIS] |
| Gene, Accession # | [CTCFL], Gene ID: 140690, NCBI: NP_001255969.1, UniProt: Q8NI51 |
| Catalog # | MBS9216953 |
| Price | $150 |
| Order / More Info | CTCFL (C-Term) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Loukinov D.I.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:6806-6811(2002). Jelinic P.,et al.PLoS Biol. 4:E355-E355(2006). Renaud S.,et al.Nucleic Acids Res. 35:7372-7388(2007). Ota T.,et al.Nat. Genet. 36:40-45(2004). Deloukas P.,et al.Nature 414:865-871(2001). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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