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Antigenic Specificity | PSEN1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for th |
Immunogen | Immunogen: A synthetic peptide of human PSEN1 Calculated Molecular Weight: 53kDa |
Other Names | [Presenilin 1: AD3; FAD; PS1; PS-1; S182], [PSEN1; PSEN1; AD3; FAD; PS1; PS-1; S182; AD3; PS1; PSNL1; PS-1; PS1-CTF12] |
Gene, Accession # | [PSEN1], Gene ID: 5663, NCBI: P49768.1, UniProt: P49768 |
Catalog # | MBS126114 |
Price | $275, $430 |
Order / More Info | PSEN1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |