TLE1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | TLE1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: TLE1 antibody detects endogenous levels of total TLE1. Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.Subunit Structure: Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif). Interacts with SIX3. Interacts with EFNB1.Post-translationa |
| Immunogen | Immunogen: A synthesized peptide derived from human TLE1 Subcellular Location: Nucleus. Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components. Tissue Specificity: In all tissues examined, mostly in brain, liver and muscle. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), C |
| Other Names | [E(Sp1) homolog; Enhancer of split groucho 1; Enhancer of split groucho like protein 1; Enhancer of split groucho-like protein 1; ESG; ESG1; GRG1; TLE1; TLE1_HUMAN; Transducin like enhancer of split 1 (E(sp1) homolog Drosophila); Transducin like enhancer of split 1; Transducin like enhancer of split 1 homolog of Drosophila E(sp1); Transducin like enhancer protein 1; Transducin-like enhancer protein 1] |
| Gene, Accession # | [TLE1], Gene ID: 7088, NCBI: NP_001290032.1, UniProt: Q04724 |
| Catalog # | MBS9608017 |
| Price | $240, $280 |
| Order / More Info | TLE1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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