NOTCH3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | NOTCH3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: NOTCH3 antibody detects endogenous levels of total NOTCH3. Description: Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate (1). Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) (2). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcript |
| Immunogen | Immunogen: A synthetic peptide of human NOTCH3 Subcellular Location: Cell Membrane and Nucleus. Following proteolytical processing NICD is translocated to the nucleus. Tissue Specificity: Ubiquitously expressed in fetal and adult tissues. |
| Other Names | [CADASIL; CASIL; NOTC3_HUMAN; Notch 3; Notch 3 intracellular domain; Notch homolog 3; Notch3] |
| Gene, Accession # | [NOTCH3], Gene ID: 4854, NCBI: NP_000426.2, UniProt: Q9UM47 |
| Catalog # | MBS9607842 |
| Price | $240, $280 |
| Order / More Info | NOTCH3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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