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Antigenic Specificity | Fyn (Phospho-Tyr530) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of Fyn only when phosphorylated at Tyrosine 530. Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeli |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of Tyrosine 530 |
Other Names | [SLK, SYN, p59-FYN] |
Gene, Accession # | [Fyn], Gene ID: 2534, NCBI: NP_002028.1, UniProt: P06241 |
Catalog # | MBS9403240 |
Price | $200, $255 |
Order / More Info | Fyn (Phospho-Tyr530) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |