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Antigenic Specificity | UBE2O |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | fluorescein (FITC) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrogr |
Immunogen | Immunogen: Recombinant human (E3-independent) E2 ubiquitin-conjugating enzyme protein Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109125 |
Other Names | [(E3-independent) E2 ubiquitin-conjugating enzyme (EC:2.3.2.242 Publications; UBE2O; KIAA1734; E2/E3 hybrid ubiquitin-protein ligase UBE2O; Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; Ubiquitin-protein ligase O], [UBE2O; UBE2O; E2-230K; KIAA1734; Ubiquitin-conjugating enzyme E2-230K] |
Gene, Accession # | [UBE2O], Gene ID: 63893, NCBI: NP_071349.3, UniProt: Q9C0C9 |
Catalog # | MBS1494824 |
Price | $160, $235 |
Order / More Info | UBE2O Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |