D4-GDI Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | D4-GDI |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mg |
| Concentration | 0.5 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background: D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeleytal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block thromugh its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28kD mature form of D4-GDI to give a 23kDa and 5kDa size fragment. The 23kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms. |
| Immunogen | Immunogen: Synthetic peptide near the N-terminus of human D4-GDI |
| Other Names | [ARHGDIB; 602843; P52566; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1], [ARHGDIB; ARHGDIB; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2; GDIA2; GDID4; RAP1GN1; Rho GDI 2] |
| Gene, Accession # | [D4-GDI], Gene ID: 397, NCBI: NP_001166.3, UniProt: P52566 |
| Catalog # | MBS841407 |
| Price | $305 |
| Order / More Info | D4-GDI Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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