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Antigenic Specificity | MAML2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of MAML2 protein. The protein encoded by MAML2 (Mastermind Like Transcriptional Coactivator 2) is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of MAML2 have been observed in several B cell-derived lymphomas. Translocations resulting in fus |
Immunogen | Immunogen: Synthesized peptide derived from part region of human MAML2 protein at amino acid sequence of 10-90 |
Other Names | [Rabbit MAML2; Mastermind-like protein 2; Mam-2] |
Gene, Accession # | [MAML2], Gene ID: 84441, NCBI: NP_115803.1, UniProt: Q8IZL2 |
Catalog # | MBS9709769 |
Price | $130, $220, $325 |
Order / More Info | MAML2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |