LTA Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | LTA |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Lymphotoxin-alpha (LT-alpha), also known as TNF-beta, is a member of the TNF superfamily of proteins (1). NK cells, T cells, B cells, and lymphoid tissue-inducer cells express LT-alpha (1). LT-alpha can be secreted as a soluble homotrimer or form membrane bound heterotrimers with lymphotoxin-beta (LT alpha1beta2 or LT alpha2beta1) which can be cleaved from the cell surface by matrix metalloproteases (1, 2). Soluble LT-alpha binds to and signals through TNFR1/TNFR2, activating the canonical NF-kappaB pathway (1). In contrast, LT alpha1beta2 heterodimers bind to the LTbetaR receptor and activate the noncanonical NF-kappaB pathway (1). As a result, LT-alpha and TNF-alpha have overlapping functions. Soluble LT-alpha and LT alpha1beta2 play key |
| Immunogen | Immunogen: Recombinant protein of human LTA Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [LT; TNFB; TNFSF1] |
| Gene, Accession # | [LTA], Gene ID: 4049, NCBI: NP_000586.2, UniProt: P01374 |
| Catalog # | MBS8505495 |
| Price | $310 |
| Order / More Info | LTA Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Wolf, M.J. et al. (2010) Oncogene 29, 5006-18. 2. Young, J. et al. (2010) Cytokine 51, 78-86. 3. Mounzer, R.H. et al. (2010) Blood 116, 2173-82. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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