CD59a, Mouse Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD59a, Mouse |
| Clone | 7A6 |
| Host Species | Mouse |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), FS, Immunoassay (IA), Immunofluorescence (IF), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody 7A6 (previously known as mCD59.3) recognizes mouse CD59a, a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 regulates the formation and function of the lytic C5b-9 complex by binding C8 and preventing the unfolding and membrane insertion of C9 and by binding C9 and restricting its polymerization.CD59 is a small (18 - 25 kDa) molecule, linked to the cell membrane through a glycosyl phosphatidylinositol (GPI) anchor and comprising 77 amino acids with a single N-linked carbohydrate group at Asn-18. Analogues of CD59 can be found in all species with similar structures and sizes. In contrast to all other species, mice have two genes encoding a CD59a and a CD59b protein. T |
| Immunogen | Immunogen: mCD59a-Fc |
| Other Names | [Membrane attack complex inhibition factor, MACIF, MAC-inhibitory protein, Protectin, CD59], [Cd59a; Cd59a; Cd59; AA987121; protectin; Cd59; MAC-IP; MACIF] |
| Gene, Accession # | [CD59a], Gene ID: 12509, NCBI: NP_001104530.1 |
| Catalog # | MBS584107 |
| Price | $535 |
| Order / More Info | CD59a, Mouse Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Harris, C et al; Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison. Immunology 2003, 109: 117 2. Williams, A et al; Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. Arthritis Rheum 2004, 50: 3035 3. Willison, H et al; The role of complement and complement regulators in mediating motor nerve terminal injury in murine models of Guillain -Barr(c) syndrome, J Neuroimmunol 2008, 201-202: 172 4. Yang, P et al; Expression and Modulation of RPE Cell Membrane Complement Regulatory Proteins. Invest Ophthalmol Vis Sci 2009, 50: 3473 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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