Mouse CD152/CTLA-4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Mouse CD152/CTLA-4 |
| Clone | [9H10] |
| Host Species | Syrian Hamster |
| Reactive Species | mouse |
| Isotype | IgG |
| Format | unconjugated |
| Size | 0.5 mg |
| Concentration | n/a |
| Applications | Flow Cytometry; Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Mouse CD152/CTLA-4 costimulatory receptor, Mr 69 kDa. CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28.^1,2 Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigenpresenting cells.^3 CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex.^1,3,4 Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2.^1,5,6. |
| Immunogen | Immunogen: Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS673518 |
| Price | $260 |
| Order / More Info | Mouse CD152/CTLA-4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Krummel, M.F., and J.P. Allison. 1995. J. Exp. Med. 182:59-465.2. June, C.H., J.A. Bluestone, L.M. Nadler, and C.B. Thompson. 1994. Immunol. Today 15:321-331.3. Perkins, D., Z. Wang, C. Donovan, H. He, et al. 1996. J. Immunol. 156:4154-4159.4. Alegre, M.-L., P.J. Noel, B.J. Eisfelder, E. Chuang, M.R. Clark, S.L. Reiner, and C.B. Thompson. 1996. J. Immunol. 157:4762-4770.5. Waterhouse, P., J.M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K.P. Lee, C.B. Thompson,, H. Griesser, and T.W. Mak. 1995. Science 270:985-988.6. Marengere, L.E.M., P. Waterhouse, G.S. Duncan, H.-W. Mittrucker, G.-S. Fneg, and T.W. Mak. 1996. Science 272:1170-1173. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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