Edit |   |
---|---|
Antigenic Specificity | FGFR2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total FGFR2 protein. Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1 (flg), FGFR2 (bek, KGFR), FGFR3, and FGFR4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and ar |
Immunogen | Immunogen Type: Peptide Immunogen Description: A synthetic peptide of human FGFR2. |
Other Names | [BEK; BFR-1; CD332; CEK3; CFD1] |
Gene, Accession # | [FGFR2], Gene ID: 2263, NCBI: NP_000132.3, UniProt: P21802 |
Catalog # | MBS9410342 |
Price | $255 |
Order / More Info | FGFR2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |