TLK2 (Center), 141-171 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | TLK2 (Center), 141-171 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 1.78 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This TLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-171 amino acids from the Central region of human TLK2. TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and |
| Immunogen | n/a |
| Other Names | [Serine/threonine-protein kinase tousled-like 2; HsHPK; PKU-alpha; Tousled-like kinase 2; TLK2] |
| Gene, Accession # | [TLK2], Gene ID: 11011, NCBI: NP_001106178.1, UniProt: Q86UE8 |
| Catalog # | MBS9202210 |
| Price | $165, $370 |
| Order / More Info | TLK2 (Center), 141-171 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Groth, A., et al., EMBO J. 22(7):1676-1687 (2003). Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Sillje, H.H., et al., EMBO J. 18(20):5691-5702 (1999). Yamakawa, A., et al., Gene 202 (1-2), 193-201 (1997). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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