Phospho-GRK2(Ser29) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-GRK2(Ser29) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-GRK2(Ser29) antibody detects endogenous levels of GRK2. Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).Subunit Structure: Interacts with GIT1 (By similarity). Interacts with, and |
| Immunogen | Immunogen: A synthesized peptide derived from human GRK2 around the phosphorylation site of Ser29. Subcellular Location: Plasma Membrane Tissue Specificity: Expressed in peripheral blood leukocytes. Predicted Cross Reactivity: Bovine, Dog, Chicken Similarity: Bovine (100%), Dog (100%), Chicken (83%) |
| Other Names | [ADRBK1; Adrenergic beta receptor kinase 1; ARBK1_HUMAN; BARK; BARK1; Beta adrenergic receptor kinase 1; Beta ARK 1; Beta ARK1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; FLJ16718; G protein coupled receptor kinase 2; G-protein coupled receptor kinase 2; GRK2] |
| Gene, Accession # | [GRK2], Gene ID: 156, NCBI: NP_001610.2, UniProt: P25098 |
| Catalog # | MBS9600637 |
| Price | $240, $280 |
| Order / More Info | Phospho-GRK2(Ser29) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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