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Antigenic Specificity | Human FADD |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunoblot (IB), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Human FADD. Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1beta-converting enzyme. FADD has also been shown under c |
Immunogen | Immunogen: Recombinant FADD. Buffer Formulation: Supplied in a stock solution in 50% glycerol/50% PBS, pH 7.4; No preservative added |
Other Names | [FAS-associated death domain protein; GIG3; MGC8528; MORT1], [FADD; FADD; GIG3; MORT1; MORT1] |
Gene, Accession # | [FADD], Gene ID: 8772, NCBI: CAG33019.1, UniProt: Q13158 |
Catalog # | MBS670616 |
Price | $375 |
Order / More Info | Human FADD Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |